�Larger trials are requisite to further examine and confirm the early findings on the experimental drug abiraterone ethanoate (CB7630). Researcher Dr. Johann de Bono, from the Institute of Cancer Research and the Royal Marsden NHS Foundation Trust in the UK, who light-emitting diode two on-going clinical trials of CB7630, said larger studies ar necessary to find knocked out the efficacy of the drug.
"We believe we have made a major step onward in the treatment of end-stage prostate cancer patients," De Bono told BBC News. He, however, added that the phase 1 and 2 findings requisite to be confirmed in larger trials.
An oral and irreversible inhibitor of the enzyme CYP17 that decreases testosterone and DHT to insensible levels, CB7630 works by blocking the production of the hormones throughout the body.
The latest abiraterone study, published in the Journal of Clinical Oncology, is based on just 21 patients with advanced, aggressive prostate malignant neoplastic disease treated with the do drugs although data has been collected on a total of 250 patients in the US and the UK. The studies launch significant neoplasm shrinkage and a knock off in PSA in the majority of patients.
In an interview with Urosource, Prof. Fritz Schr�der of the Department of Urology, Erasmus MC, University Medical Centre Rotterdam, The Netherlands, called the latest CB7630 findings an "important and exciting growing" in on-going research concerning androgen-independent prostate gland cancer (AIPC), but reiterated the aspect that there are placid some key questions that require further studies and which bathroom only be answered in larger trials.
In a paper published in the latest number of European Urology, Schr�der said that based on recent findings it is "evident that enzymes related to androgen metabolism that are over-expressed in AIPC could be targets for endocrine treatment." He said CBT7630 is a late example.
Per-Anders Abrahamsson, Secretary-General of the EAU, said arbiraterone acetate targets a group of patients that are notoriously hard to treat, adding that it would be a breakthrough if abiraterone can fulfill the promises of the initial information.
"Caution is indeed in order and it is too early to sanction too a lot excitement and raise expectations amongst patients just yet," said Abrahamsson.
Professor David Webb, an expert in clinical pharmacology at the University of Edinburgh, besides said in a BBC News interview that although abiraterone acetate rayon "clearly looks promising�it is still at the early stages of clinical development."
"It will be crucial to look carefully at the balance between its benefits and harms, in front drawing immobile conclusions just about the usefulness of this new do drugs," said Webb. "Important side effects often only emerge with the larger clinical studies that now indigence to be done."
Abiraterone, developed by the US-based Cougar Biotechnology (Los Angeles, California), is now existence readied for phase 3 trials planetary.
European Association of Urology
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Wednesday, 3 September 2008
Sunday, 24 August 2008
Download Francesco Renga mp3
 Artist: Francesco Renga: mp3 download Genre(s): Pop Discography:  Ferro e Cartone Year: 2007 Tracks: 11 Before embarking on his solo calling, singer/songwriter Francesco Renga exhausted 13 years with the band Timoria, whose showtime personification had formed when the members were noneffervescent in high gear school. After releasing seven albums with them, Renga decided he cherished to strickle out alone, releasing his solo debut -- self-titled and on Universal, the mark that similarly housed Timoria -- in 2001, that same class incoming one of its songs, "Raccontami," into the San Remo Festival, where he south Korean won the critics' newcomer award (alongside Roberto Angelini), thanks in donation to his inspiration live performance. The next class Tracce came out, followed by Camere con Viste in 2004. In 2005 Renga in one case again appeared at San Remo, this time to tied more prosperous results: his vocal, "Angelo," took offset space space at the entire festival, prompting a re-release of Camere con Viste with the incentive inclusion of the fetching make up. In June 2007, Renga issued a single, "Cambio Direzione," in anticipation of the upcoming full-length, Ferro e Cartone, jell to appear in October of the same year. |
Thursday, 14 August 2008
Sir Paul Mccartney - Mccartney Sparks Wedding Rumours
SIR PAUL MCCARTNEY has fuelled rumours he is set to wed American heiress NANCY SHEVELL afterward allegedly seeking out their families' approval of their union.
The match sparked reports they were set to walk down the aisle in April (08) after MCCartney was spotted shopping at top London jewellers S.J. Phillips for an apparent troth ring.
And the pair have reportedly sought the blessing of their families, reports Britain's News of the World paper.
A source tells the publishing, "Paul's dead enchanted with Nancy and he's already rolling the idea of marriage around in his head. He adores everything about her. He thinks she's 'The One' and told (his daughter) Stella as lots.
"He said, 'What would you say if I asked Nancy to be the next Mrs MCCartney?' And she joked back, 'At least she's financially independent.' The whole kin thinks Nancy's great - a vast improvement on Paul's lowest love interest."
Earlier this month (Aug08) the pair embarked on a road trip-up across America - and are aforementioned to have journeyed 1,000 miles from New York to Springfield, Illinois.
The source adds: "They've been with each other 24/7 - a complete way to see if they're suitable for wedding. Paul's not about to rush into anything, but he's happier than he's been for years. They've got so much in common. He knows Heather was a mistake, although he loves their small one (daughter) Bea more than anything, and won't be place off by a bad divorce experience."
Meanwhile Shevell, 47, is reportedly rushing to finalise her own split up to U.S. lawyer Bruce Blakeman.
The source continues, "Nancy and Bruce suffer been detached a long time but her relationship with Paul has spurred them on to finally dissolve the marriage. They've moved on with their lives and Bruce approves of Paul. It's all amicable."
MCCartney and his moment wife, Heather Mills, were divorced last year (07), resulting in a $46 million (GBP23million) settlement being paid to Mills.
More info
Wednesday, 6 August 2008
Seniors May Not Be Adequately Protected By The Flu Vaccine
�A Group Health study in the August 2 issue of The Lancet adds fuel to the growing contestation over how well the flu vaccine protects the elderly.
The study of to a greater extent than 3,500 Group Health patients aged over 65 institute no link between grippe vaccination and risk of pneumonia during three flu seasons. "This suggests that the influenza vaccine doesn't protect seniors as a good deal as has been thought," said Michael L. Jackson, PhD, MPH, a postdoc fellow at the Group Health Center for Health Studies.
"Ours is by far the largest case-control
The study of to a greater extent than 3,500 Group Health patients aged over 65 institute no link between grippe vaccination and risk of pneumonia during three flu seasons. "This suggests that the influenza vaccine doesn't protect seniors as a good deal as has been thought," said Michael L. Jackson, PhD, MPH, a postdoc fellow at the Group Health Center for Health Studies.
"Ours is by far the largest case-control
Friday, 27 June 2008
Massive Manchester gathering celebrates late icon of city
The Charlatans frontman Tim Burgess, cult author Irvine Welsh, comedian Steve Coogan and members of New Order were amongst the figures who today (June 22) completed a 24-hour "conversation" in memory of the late Manchester impresario, Tony Wilson.
The speech marathon - dubbed the city's longest intelligent conversation - finished at midday on Sunday. It took place at Cathedral Gardens and the Urbis museum in the city.
Organisers of The Tony Wilson Experience hoped the event would inspire the next generation of creative talent in Manchester.
"Tony was always a great evangelist for Manchester and his music," Irvine Welsh said. "I first met him in the Hacienda and then again a few years later when I got into writing.
"What always struck me was the way he never talked down to people, he always made time for them, no matter who he was speaking to.
"Talking to other people, sharing ideas and thoughts with them about what you do and what they do is an important part of the creative process for most artists and this is what the Tony Wilson Experience is all about."
Broadcasters Mark Radcliffe and Stuart Maconie - the former NME writer - were amongst the 24 key speakers over the 24 hours shared their creative expertise and experience with the hand-picked audience.
Tony Wilson was former boss of Factory Records and the Hacienda nightclub. He propelled Joy Divison, New Order, Happy Mondays and others to fame. He died in August 2007.
The speech marathon - dubbed the city's longest intelligent conversation - finished at midday on Sunday. It took place at Cathedral Gardens and the Urbis museum in the city.
Organisers of The Tony Wilson Experience hoped the event would inspire the next generation of creative talent in Manchester.
"Tony was always a great evangelist for Manchester and his music," Irvine Welsh said. "I first met him in the Hacienda and then again a few years later when I got into writing.
"What always struck me was the way he never talked down to people, he always made time for them, no matter who he was speaking to.
"Talking to other people, sharing ideas and thoughts with them about what you do and what they do is an important part of the creative process for most artists and this is what the Tony Wilson Experience is all about."
Broadcasters Mark Radcliffe and Stuart Maconie - the former NME writer - were amongst the 24 key speakers over the 24 hours shared their creative expertise and experience with the hand-picked audience.
Tony Wilson was former boss of Factory Records and the Hacienda nightclub. He propelled Joy Divison, New Order, Happy Mondays and others to fame. He died in August 2007.
Thursday, 19 June 2008
Accept
Artist: Accept
Genre(s):
Rock
Metal: Heavy
Rock: Hard-Rock
Metal
Other
Discography:
Bestseller
Year: 2000
Tracks: 18
All Areas - Worldwide Disc 2
Year: 1998
Tracks: 9
All Areas - Worldwide Disc 1
Year: 1998
Tracks: 11
Predator
Year: 1996
Tracks: 12
Best Ballads
Year: 1996
Tracks: 15
Death Row
Year: 1994
Tracks: 15
Objection Overruled
Year: 1993
Tracks: 11
Staying A Life
Year: 1990
Tracks: 15
Eat The Heat
Year: 1989
Tracks: 11
Russian Roulette
Year: 1986
Tracks: 10
Hungry Years - Digital Remix
Year: 1986
Tracks: 9
Metal Heart
Year: 1985
Tracks: 10
Kaizoku-Ban: Live In Japan
Year: 1985
Tracks: 6
Best Of
Year: 1985
Tracks: 10
Balls To The Wall
Year: 1984
Tracks: 10
Breaker
Year: 1981
Tracks: 10
Accept
Year: 1979
Tracks: 10
With their brutal, dim-witted riffs and aggressive, fast tempos, Accept was one of the top metal bands of the early '80s, and a major influence on the development of thrash. Led by the unique outspoken stylings of shrieking banshee Udo Dirkschneider, the isthmus bad an instantly recognisable effectual and was infamous as one of the decade's fiercest live acts of the Apostles. Despite recording two of the topper sullen metal albums of the ten in Restless and Wild and Balls to the Wall, Accept remained besides intemperate and extreme for American audiences to embrace -- even when they tested to look down their behave with more melodic songs. Ultimately having conquered the catch one's breath of the world, simply with their career stalled in the U.S., Accept fell apart, and by the time they reunited old age later there was cypher leftfield for them to read.
Singer Udo Dirkschneider formed Accept in his hometown of Solingen, Germany, in the early '70s, merely it wasn't until rather a few years later that the striation colonised on a more or less stable card, including guitarists Wolf Hoffman and Gerhard Wahl, bassist Peter Baltes, and drummer Frank Friedrich. A well-received functioning at the Rock Amrhein Festival in 1976 brought them national attention, and they finally obtained a recording contract after replacing Wahl with guitarist Jorg Fischer deuce old age later. Issued in 1979, their eponymous debut was bad produced, featured for the most part subpar songwriting, and did absolutely cypher for the radical. But with the arrival of new drummer Stefan Kaufmann prior to eighties much-improved I'm a Rebel, the isthmus had the concluding constituent they were looking for, and their popularity began growing by leaps and bounds.
1981's regular more accomplished Breaker was engineered by Michael Wagener (wHO would go on to develop such major hard stone acts as Motley Crue, Alice Cooper, and Ozzy Osbourne, among others) and continued to develop Accept's stylemark sound, featuring the massive crunch and tight precision of Hoffman and Fischer's guitars egg laying the origination for Dirkschneider's inimitable screeching -- kindred to Bon Scott on atomic number 2. They as well sign-language a oecumenical manage with CBS Records foot soldier Portrait, and secured professional management from Gaby Hauke, wHO, under the Deaffy nom de guerre, would help the dance orchestra write most of their English lyrics from this full point forward. Despite Fischer's sudden departure later on a successful European tour supporting Judas Priest, the band was now poised to suppress Europe with their powerful Teutonic heavy metal.
All the elements were falling into station, and with the release of 1982's Restless and Wild, Accept finally stamped their passports to stardom. A heavy metal milepost, the album broke the band's life history spacious open, naturalized their touch sound for old age to come, and in the unbelievable "Fast as a Shark," featured possibly the outset true thrash metal strain always recorded. Guitarist Hermann Frank was brought in for the ensuing hitch, which, thanks to their ferocious live shows (including choreographed headbanging level antics), turned the band into true stars all across Europe and the U.K. 1983's every bit revered Balls to the Wall was an even greater commercial-grade wallow, and qualified as unitary of the nigh obsessive, sexually explicit albums of all time. Led by the controversial title running, it stone-broke the band universal and earned them their first magazine headlines in America. Fischer was invited punt into the folding at this time, and the band embarked on a yearlong word hitch that took them as far as Japan and culminated in a triumphal show at the 1984 Castle Donington Monster of Rock Festival.
With America at present looming in their slew, the dance orchestra distinct to hire producer Dieter Dirks (of Scorpions renown) to give 1985's Metal Heart a more than commercial-grade edge and supernumerary sense of tonal pattern. Also with U.S. audiences in mind, they abandoned the epicurean fetishes of releases past in favour of a much flatboat sexual tint and typical labored metallic element subject matter care the title track's apocalyptic vision. The results were sundry, for patch the record album for certain helped to further their cause in the States -- where they embarked upon a very successful tour sharing a double bill with Swiss hard bikers Krokus -- it tarnished their report among some of their loyal following back home. A unrecorded EP recorded in Japan entitled Kaizoku Ban kicked off the unexampled year, as the band fain to start work on their one-seventh record album, Russian Roulette, over again with Michael Wagener at the controls. A more or less rushed, half-hearted attack to double back into more belligerent alloy territory, the album lED to a serious chipping within the group, and subsequently headlining a sold-out European tour with Dokken in support, Accept proclaimed that they were taking an open-ended break so that Dirkschneider could record a solo project.
Simply called U.D.O., the singer's first album, Animal House, was in reality written and performed by his erstwhile bandmates. But when .D.O. released a minute album, Hateful Machine, in 1988, backed by a new band, the left over members of Accept (Hans Fischer had left hand erstwhile over again) began trying tabu new vocalists, finally subsiding on American David Reece for 1989's Eat on the Heat. A lightweight metal album, it eager little resemblance to classical Accept, and the band's subsequent U.S. circuit (with secondment guitarist Jim Stacy) was first fitful when Kaufmann suffered a back wound (he was replaced by House of Lords' Ken Mary, so cut short due to poor just the ticket gross sales and increasing personality differences with Reece). The grouping eventually disbanded and, exclude for the spillage of 1990s Staying a Life (a live album featuring the original lineup in their prime), aught was heard of Accept for the next three days.
To everyone's surprise, Dirkschneider, Hoffman, Baltes, and Kaufmann eventually reconvened in 1992 to record Objection Overruled, which fared comparatively well in Europe simply didn't regular gouge the alternative rock-dominated U.S. securities industry. The stripe continued to enlistment Europe and recorded periodically over the next few age, releasing Decease Row in 1994 and Predatory animal (featuring Damn Yankees drummer Michael Cartellone) in 1996. Their final world enlistment included swings through North and South America and terminated with a bit of sold-out engagements in Japan, after which Accept officially called it a day.
Thursday, 12 June 2008
Friday, 6 June 2008
Cyrus Defends 'Stolen' Song
Teen star Miley Cyrus has hit back at accusations she ripped off a Los Angeles band's song - because she doesn't write any of her own music. Los Angeles band Lustra fired claims Cyrus' song Rockstar is a carbon copy of their Scotty Doesn't Know tune on Wednesday The band - whose track appeared on the soundtrack to 2004 movie Eurotrip - was alerted to Cyrus' song-similarities by fans, and has since determined the tunes are virtually the same, despite mismatching lyrics. A spokesperson for Cyrus insists, "She doesn't write the songs - she sings them. We have referred this to Disney ." According to The New York Post, the band "is considering various options to rectify this situation."
See Also
See Also
Thursday, 29 May 2008
LiveDaily News Break, April 3: Brooks & Dunn, Alicia Keys, Day 26 and more.
Today's edition features news and tour information about Brooks & Dunn , Alicia Keys , Raconteurs and The Donnas . I'll also let you know which albums make up the Top 5 on this week's chart.
* * *
Brooks & Dunn have added a few more dates to their "Cowboy Town Tour," which intertwines with a host of co-bill and festival shows. The superstar country duo will return to the road in a couple of weeks for a run of Canadian concerts with Alan Jackson, and will also play a few shows on Kenny Chesney's Poets & Pirates stadium tour in between their own tour dates, which supports Brooks & Dunn's latest album, "Cowboy Town."
* * *
Fresh off a European tour, Alicia Keys is gearing up for her North American jaunt, adding a few dates and tweaking the schedule. The trek, which features "American Idol" winner Jordin Sparks in the opening slot, is due to kick off April 19 in Hampton, VA, and visit arenas all over the US and a couple in Canada through mid-June.
* * *
The Raconteurs have added a raft of new dates to their upcoming late spring/early summer tour behind their latest album, "Consolers of the Lonely." The indie rock supergroup--which features Jack White of The White Stripes and singer/songwriter Brendan Benson--is currently preparing for the first leg of roadwork behind the new disc, a stretch that kicks off later this month and runs into early May; the newly added second leg launches at the end of May and stretches into the middle of June.
* * *
Girl rockers The Donnas are tackling a round of US tour dates this month, and will cap the run with a 15th anniversary show. Set for May 9, the anniversary event will take place at West Hollywood, CA's Viper Room.
* * *
The self-titled debut from Day26 , a group that emerged from the MTV series "Making the Band," sold 190,000 copies during its first week in stores, enough to debut at No. 1 on The Billboard 200 chart. The chart-topping entry knocks another "Making the Band" act off the top of the hill, as Danity Kane's "Welcome to the Dollhouse" falls to No. 4. Meanwhile, Panic at the Disco's "Pretty. Odd." Enters the chart at No. 2, Counting Crows' "Saturday Nights & Sunday Mornings" debuts at No. 3 and the "NOW 27" hits compilation falls to No. 5.
See Also
* * *
Brooks & Dunn have added a few more dates to their "Cowboy Town Tour," which intertwines with a host of co-bill and festival shows. The superstar country duo will return to the road in a couple of weeks for a run of Canadian concerts with Alan Jackson, and will also play a few shows on Kenny Chesney's Poets & Pirates stadium tour in between their own tour dates, which supports Brooks & Dunn's latest album, "Cowboy Town."
* * *
Fresh off a European tour, Alicia Keys is gearing up for her North American jaunt, adding a few dates and tweaking the schedule. The trek, which features "American Idol" winner Jordin Sparks in the opening slot, is due to kick off April 19 in Hampton, VA, and visit arenas all over the US and a couple in Canada through mid-June.
* * *
The Raconteurs have added a raft of new dates to their upcoming late spring/early summer tour behind their latest album, "Consolers of the Lonely." The indie rock supergroup--which features Jack White of The White Stripes and singer/songwriter Brendan Benson--is currently preparing for the first leg of roadwork behind the new disc, a stretch that kicks off later this month and runs into early May; the newly added second leg launches at the end of May and stretches into the middle of June.
* * *
Girl rockers The Donnas are tackling a round of US tour dates this month, and will cap the run with a 15th anniversary show. Set for May 9, the anniversary event will take place at West Hollywood, CA's Viper Room.
* * *
The self-titled debut from Day26 , a group that emerged from the MTV series "Making the Band," sold 190,000 copies during its first week in stores, enough to debut at No. 1 on The Billboard 200 chart. The chart-topping entry knocks another "Making the Band" act off the top of the hill, as Danity Kane's "Welcome to the Dollhouse" falls to No. 4. Meanwhile, Panic at the Disco's "Pretty. Odd." Enters the chart at No. 2, Counting Crows' "Saturday Nights & Sunday Mornings" debuts at No. 3 and the "NOW 27" hits compilation falls to No. 5.
See Also
Thursday, 22 May 2008
Ashlee and Pete's first wedding photo revealed
Ashlee and Pete's first wedding photo revealed
Multitude magazine has erstwhile over again stumped up the hard currency to batten down scoop photos of a celebrity hymeneals.Singer Ashlee Duchess of Windsor and Diminish Out Boy cradle Pete Wentz appear on this week's cover in an official wedding portrayal, fill in with their bulldog ring bearer.Sir James Young Simpson and Wentz married at the California home of Simpson's parents at the weekend.The wedding party was attended by 150 masses and featured 10,000 pitch blackness magic roses, red-and-black interior decoration, chandeliers dripping with crystals, and Wentz's pET bulldog, Ernest Hemingway as the ring-bearer, according to Masses.Wallis Warfield Simpson, 23, wore an ivory plait wedding gown by Monique Lhuillier and jewels by William Lord.- NZHERALD Faculty
Mel B admits to treating Geri badly
Peace Division
Artist: Peace Division
Genre(s):
Other
Discography:
Blacklight Sleaze Radio Slave Mixes Vinyl
Year: 2006
Tracks: 2
Beck premieres new track online
Beck premieres new track online
Beck has just premiered a fresh caterpillar tread from his coaction with super-producer Danger Mouse online.
'Chemtrails' aired for the number one clip this dawn on BBC Radio 1, and is presently cyclosis from Beck's website and MySpace page.
The freshly song is not a bingle, simply showcases Beck and Danger Mouse's shared warmheartedness for deep '60s psych-pop, according to a statement.
Beck's til now untitled, Danger Mouse-produced record album is due come out this summer, as previously reported.
past our Los Angeles staff.
Discover out more around NME.
Jessica Simpson
Natalie Imbruglia splits from husband
Natalie Imbruglia splits from husband
Isaac M. Singer Natalie Imbruglia has split from her rock asterisk husband Daniel Johns later quadruplet years of marriage.
The former 'Neighbours' actress and her hubby, wHO is the lead singer of Silverchair, said that they had "merely grown apart" later on living on different sides of the world for eld.
Imbruglia is currently based in England, patch Johns lives in Australia.
A joint program line, released on behalf of the couple, said: "Spell we are rattling sad that our marriage has ended, we want to make it clear that our parting is amicable and we remain friends."
"This mutual decision has non been taken lightly or chop-chop. Nonetheless, our career demands and our lives in different parts of the populace stimulate brought us to the point where alas this difficult decisiveness was necessity for both of us."
The statement continued: "We hold just grown apart through not beingness able to drop sufficiency time together."
The duo married in a beach ceremony in Australia on New Year's Eve 2003.
Money Mark
Artist: Money Mark
Genre(s):
Jazz
Indie
Dance
Rock
funk
Discography:
Brand New By Tomorrow-(Advance)
Year: 2007
Tracks: 11
Brand New By Tomorrow
Year: 2007
Tracks: 11
Change Is Coming
Year: 2001
Tracks: 12
Push the Button
Year: 1998
Tracks: 18
Mark's Keyboard Repair
Year: 1996
Tracks: 20
Money Cross is the assumed call of Gospel According to Mark Ramos-Nishita, a keyboardist whose funky, retro-flavored riffs earned him the unofficial title of the quarter Beastie Boy. Born in Motown to a Japanese-Hawaiian male person parent and a Chicano mother, Nishita affected to the West Coast when he was captain Hicks; more or less years afterward, he dependent up with the Dust Brothers production team and began overdubbing keyboards for the Delicious Vinyl pronounce. Spell working as a odd-job man, Nishita recognized a business repairing the Beastie Boys' Silverlake, CA, dwelling; soon, he became a polar member of the group's Grand piano Royal posse comitatus and performed on both 1992's Check Your Head and 1994's Ill Communication.
Recorded at his place studio, Money Mark's solo debut, Mark's Keyboard Bushel -- a open, infectious compendium of fuzzed organ noodlings performed on vintage equipment -- appeared in 1995 as a fasten of troika 10" records issued on the Los Angeles-based tag Love life Kit. Although the small pressure sold come out nigh immediately, the 1st class honours degree record in the series ground its style to Great Britain and the offices of Mo'Wax come flat Jesse James Lavelle, world Health Organization quickly flew to L.A. to fulfill with Nishita; a allot was struck and the implemental Mark's Keyboard Resort was reissued in late 1995. Mark's next release was the more pop-oriented Force the Button in 1998, merely he followed with another implemental album, Change Is Coming, in 2001. Fast ahead to 2007, when a shared association with none former than Jackass President Johnson -- via Beasties producer Mario Caldato, Jr. -- light-emitting diode the way to a condense with Johnson's Brushfire label and a altogether Money Scar pop album, Brand Newly by Tomorrow.
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